Publications

Peer Reviewed Journals

Wongkummool W, Maneepitasut W, Tong-Ngam P, Tangprasittipap A, Munkongdee T, Boonchuay C, Svasti S, Kitiyanant N, Paiboonsukwong K, Fucharoen S, Tubsuwan A. Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2. Stem Cell Res. 2017 Apr;20:80-83. doi: 10.1016/j.scr.2017.02.012.

Wongkummool W, Maneepitasut W, Munkongdee T, Tong-Ngam P, Tangprasittipap A, Svasti S, Kitiyanant N, Paiboonsukwong K, Fucharoen S, Tubsuwan A. Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring. Stem Cell Res. 2017 Apr;20:84-87. doi: 10.1016/j.scr.2017.02.014.

Tangprasittipap A, Jittorntrum B, Wongkummool W, Kitiyanant N, Tubsuwan A. Generation of induced pluripotent stem cells from peripheral blood CD34+ hematopoietic progenitors of a 31-year-old healthy woman. Stem Cell Res. 2017 Apr;20:91-93. doi: 10.1016/j.scr.2017.02.013.

Zhang Y., Schmid B, Nikolaisen N.K., Rasmussen M.A., Aldana B.I., Agger M., Calloe K., Stummann T.C., Larsen H.M, Nielsen T.T, Huang J., Xu F., Liu X., Bolund L., Meyer M., Bak L.K., Waagepetersen H.S., Luo Y., Nielsen J.E., The FReJA Consortium, Holst B., Clausen C., Hyttel P. and Freude K.K. Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Stem Cell Reports, 8(3), 1-11, 2017. doi: 10.1016/j.stemcr.2017.01.012.

Ochalek, A; Mihalik, B; Avci, HA; Chandrasekaran, A; Téglási, A; Bock, I; Giudice, ML; Táncos, Z; Molnár, K; László, L; Nielsen, JE; Holst, B; Freude, K; Hyttel, P; Kobolák, J; Dinnyes, A. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels and GSK3B activation. Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z

Chandrasekaran, A, Avci, HX, Ochalek, A, Rösingh, LN, Molnár, K, László, L, Bellák, T, Téglási, A, Pesti, K, Mike, A, Phanthong, Hall, V, Kitiyanant, N, Krause, KH, Kobolák, J and Dinnyés A. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human iPSCs. Stem Cell Research; Accepted date: 10 October 2017; doi:10.1016/j.scr.2017.10.010

Pires C, Schmid B, Petræus C, Poon A, Nimsanor N, Nielsen TT, Waldemar G, Hjermind LE, Nielsen J, Hyttel P and Freude KK. Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1. Stem cell Research 17 285-288, 2016. doi:10.1016/j.scr.2016.08.002

Nimsanor, M., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line derived from a pre-symptomatic 28-year-old female patient with frontotemporal dementia caused by a R406W mutation in microtubule associated protein tau (MAPT). Stem Cell Research 17(3): 600-602, 2016. doi:10.1016/j.scr.2016.09.024

Nimsanor, M., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research 17(3): 576-579, 2016 doi: 10.1016/j.scr.2016.09.020

Nimsanor, N., Jørring, I., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Kitiyanant, N., Nielsen, J.E., Nielsen, T.T. Hyttel, P., Holst, B. and Schmid, B.: Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Stem Cell Research 17(3): 564-567, 2016. doi:10.1016/j.scr.2016.10.006

Nimsanor, N., Kitiyanant, N., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research 17(3): 556-559, 2016. doi:10.1016/j.scr.2016.09.021

Nimsanor, N., Jørring, I., Rasmussen, M.A., Clausen, C., Mau-Holzmannb U.A., Bus C., Hoffmann, S.A., Gasser, T., Kluba, T., Holst, B. and Schmid, B.: Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases. Stem Cell Research 17(3): 550-552, 2016. doi:10.1016/j.scr.2016.09.019

Secher, J.O., Ceylan, A., Mazzoni, G., Mashayekhi, K., Li, T., Muenthaisong, S., Nielsen, T.T.,  Li, D., Li, S., Petkov, S., Cirera, S.,  Luo, Y.,Thombs, L., Kadarmideen, H., N.,  Dinnyes, A., Bolund, L., Roelen , B. A. J., Schmidt, M., Callesen, H.,  Hyttel, P.,  Freude, K.K Systematic in Vitro and in Vivo Characterization of Leukemia-Inhibiting Factor- And Fibroblast Growth Factor-Derived Porcine Induced Pluripotent Stem Cells. Molecular Reproduction & Development, 3 January 2017, 84(3), pp: 229-245. doi: 10.1002/mrd.22771

Schmidt BZ, M. Lehmann, S. Gutbier, E. Nembo,S. Noel,  L. Smirnova, A. Forsby,J.  Hescheler, H. X. Avci, T.  Hartung,  M. Leist,  J. Kobolák, A. Dinnyés. In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high‑throughput technical possibilities. Archives of Toxicology, 04 August 2016, 91(1), pp: 1-33. doi: 10.1007/s00204-016-1805-9

Poon A, Zhang Y, Chandrasekaran A, Phanthong P, Schmid B, Nielsen TT, Freude KK. Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges. N Biotechnol. 2017 Jun 2. pii: S1871-6784(16)32499-2. doi: 10.1016/j.nbt.2017.05.009.

Phathong, P., Borwornpinyo, S., Kitiyanant, N., Jearawiriyapaisarn, N., Nunzakarn, L., Saetan, J. Nualkaew, T. Sa-Ngiamsuntorn, K., Anurathapan, U., Dinnyes, A.,Kitiyanant, Y., Hongeng, S. . (2017). Enhancement of b-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Stem Cells Tranlational Medicine. 18 February 2017, 6(4) pp:1059-1069 doi: 10.1002/sctm.16-0121.

Pajera K, Cs. Nemes, S. Berzsenyi, K. A. Kovács, M. K. Pirity, G. Pajendac, A. Nógrádia, A., Dinnyés. Grafted murine induced pluripotent stem cells prevent death of injured rat motoneurons otherwise destined to die. Experimental Neurology,16 May 2015, 269, pp: 188-201. doi: 10.1016/j.expneurol.2015.03.031

Ochalek A, K. Szczesna, P. Petazzi,J. Kobolak,A. Dinnyes. (2016). Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy. Stem Cells International, 26 December 2016, 2016, pp: 1-16. doi: 10.1155/2016/5838934.

Nagy J, Kobolák J, Berzsenyi S, Ábrahám Z, Avci H X, Bock I,Bekes Z,Hodoscsek B,Chandrasekaran A,Téglási A, Dezső P,Koványi B,Vörös E T,Fodor L,Szél T, Németh K, Balázs A,Dinnyés A, Lendvai B,Lévay G,Román V. Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism. Translational Psychiatry  2017  July 25, 7, e1179; doi:10.1038/tp.2017.144

Chandrasekaran, A., Avci, H.X., Leist, M., Kobolák, J., Dinnyés, A. Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research. Frontiers in Cellular Neuroscience, 26 September 2016, 10(215), pp: 1-27. doi: 10.3389/fncel.2016.00215

Poon A, Li T, Pires C, Nielsen TT, Nielsen JE, Holst B, Dinnyes A, Hyttel P, Freude KK. Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1. Stem Cell Res. 2016 Nov;17(3):470-473. doi: 10.1016/j.scr.2016.09.016.

Poon A, Schmid B, Pires C, Nielsen TT, Hjermind LE, Nielsen JE, Holst B, Hyttel P, Freude KK. Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1. Stem Cell Res. 2016 Nov;17(3):466-469. doi: 10.1016/j.scr.2016.09.018.

Hansen SK, Stummann TC, Borland H, Hasholt LF, Tümer Z, Nielsen JE, Rasmussen MA, Nielsen TT, Daechsel JC, Fog K, Hyttel P. Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. Stem Cell Res. 2016 Sep;17(2):306-317. doi: 10.1016/j.scr.2016.07.004.

Secher JO, Callesen H, Freude KK, Hyttel P. Initial embryology and pluripotent stem cells in the pig—The quest for establishing the pig as a model for cell therapy. Theriogenology. 2016 Jan 1;85(1):162-71. doi: 10.1016/j.theriogenology.2015.09.017.

Hansen S.K., Borland H., Hasholt L.F., Tümer Z., Nielsen J.E., Rasmussen M.A., Nielsen T.T., Stummann T.C., Fog K. and Hyttel P.: Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11. Stem Cell Res. 2016 May;16(3):553-6. doi: 10.1016/j.scr.2016.02.040

Hansen S.K., Borland H., Hasholt L.F., Tümer Z., Nielsen J.E., Rasmussen M.A., Nielsen T.T., Stummann T.C., Fog K. and Hyttel P.: Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11. Stem Cell Res. 2016 May;16(3):589-92.

Li T., Pires C., Nielsen T.T., Waldemar G., Hjermind L.E., Nielsen J.E., Dinnyes A., Holst B., Hyttel P. and Freude K.K. Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1. Stem Cell Research 2016, 16(2):334-337.

Li T., Pires C., Nielsen T.T., Waldemar G., Hjermind L.E., Nielsen J.E., Dinnyes A., Hyttel P. and Freude K.K.: Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1. Stem Cell Research 2016, 16(2):229-232. doi: 10.1016/j.scr.2016.01.002.

Zhou S., Ochalek A., Szczesna K., Avci H.X., Kobolák J., Varga E., Rasmussen M., Holst B., Cirera S., Hyttel P., Freude K.K. and Dinnyés A.: The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF. Differentiation.  2016 Jun 16. doi: 10.1016/j.diff.2016.06.002. [Epub ahead of print]

Zhang Y., Schmid B., Nielsen T.T., Nielsen. J.E., Clausen C., Hyttel P., Holst B. and Freude K.K.: Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B. Stem Cell Research 17(1): 148-150, 2016

Zhang Y., Schmid B., Nielsen T.T., Nielsen. J.E., Clausen C., Hyttel P., Holst B. and Freude K.K.: Generation of a human induced pluripotent stem cell line viaCRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B. Stem Cell Research 17(1): 151-153, 2016.

Táncos Z., Varga E., Kovács E., Dinnyés A. and Kobolák K.: Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 75-77, 2016.

Nemes C., Varga E., Táncos Z., Bock I., Francz B., Kobolák J. and Dinnyés A.: Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient. Stem Cell Research 17(1): 69-71, 2016.

Chandrasekaran A., Varga E., Nemes C., Táncos Z., Kobolák J. and Dinnyés A.: Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 78-80, 2016.

Ochalek A., Nemes C., Varga E., Táncos Z., Kobolák J. and Dinnyés A.: Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 72-74, 2016.

Táncos Z., Varga E., Kovács E., Dinnyés A. and Kobolák J.: Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 81-83, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research, 16(1): 202-205, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem Cell Research, 16(1): 199-201, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem Cell Research, 16(1): 180-183, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen, J.E. and Holst B.: Generation of Spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research, 16(1): 166-169, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem Cell Research, 16(1): 162-165, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem Cell Research, 16(1): 159-161, 2016

Tubsuwan A., Pires C., Rasmussen M.A., Schmid B., Nielsen J.E., Hjermind L.E., Hall V., Nielsen T.T., Waldermar G., Hyttel P., Clausen C., Kitiyanant N., Freude K.K. and Holst B.: Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer’s disease patient carrying a L150P mutation in PSEN-1. Stem Cell Research, 16(1): 110-112, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia. Stem Cell Research, 16(1): 105-109, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1): 75-78, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1): 70-74, 2016.

Tangprasittipap A, Satirapod C, Jittorntrum B, Lertritanan S, Anurathaphan U, Phanthong P, Borwornpinyo S, Kitiyanant N, Hongeng S. Tangprasittipap A., Satirapod C, Jittorntrum B, Lertritanan S, Anurathaphan U, Phanthong P, Borwornpinyo S, Kitiyanant N, Hongeng S. Generation of iPSC line MU011.A-hiPS from homozygous α-thalassemia fetal skin fibroblasts. Stem Cell Res. 2015 Nov;15(3):506-9. doi: 10.1016/j.scr.2015.09.003.

Zhou S., Szczesna K., Ochalek A., Kobolák J., Varga E., Nemes C., Chandrasekaran A., Rasmussen M., Cirera S., Hyttel P., Dinnyés A., Freude K.K., and Avci H.X.: Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells International, Aug. 2015.

Høffding M.K., Hyttel P: Ultrastructural visualization of the Mesenchymal-to-Epithelial Transition during reprogramming of human fibroblasts to induced pluripotent stem cells. Stem CellResearch, Nov. 2014.

Rasmussen M.R., Holst B., Tümer Z., Johnsen M.G., Zhou S., Stummann T.C., Hyttel P., and Clausen C.: Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage. Stem Cell Reports, Vol. 3, 404–413, September 9, 2014.

Varga E , Juhász G, Bozsó Z, Penke B, Fulop L, and Szegedi V: Abeta (1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors. Neural Plasticity, Sept. 2014.

Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A: Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Exp Cell Res. 2014 Apr 1;322(2):335-44.

Nemes C, Varga E, Polgar Z, Klincumhom N, Pirity MK, Dinnyes A.: Generation of Mouse Induced Pluripotent Stem Cells by Protein Transduction. Tissue Eng Part C Methods, 2013 Oct 12. Epub 2013 Oct 10.

Phanthong P, Raveh-Amit H, Li T, Kitiyanant Y, Dinnyes A.: Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells. Biogerontology, 2013 Dec;14(6):591-602. doi: 10.1007/s10522-013-9455-2. Epub 2013 Aug 21.

 

Book Chapters

Rungarunlert, S., Ferreira J.N., Dinnyes A. Novel Bioreactor Platform for Scalable Cardiomyogenic Differentiation from Pluripotent Stem Cell-Derived Embryoid Bodies In: Methods in Molecular BiologyBioreactors in Stem Cell Biology 5 April 2016, 1502 pp:169-179 doi: 10.1007/7651_2016_341 ISBN 978-1-4939-6478-9

Pires C, Hall V and Freude KK. Human Induced Pluripotent Stem Cells and their Derivatives for Disease Modeling and Therapeutic Applications in Alzheimer’s Disease. Alzheimer's disease. SMGroup, 2016. p. 1-25. ISBN: 978-1-944685-98-0

Conference proceedings 

2017

Dinnyes A.,Chandrasekaran A., Avci H., Ochalek A., Molnar K., Laszlo L., Bellak T., Pesti K., Mike A., and Kobolak J. Comparison of 2D and 3D human iPSC neural induction methods for the generation of neural progenitor cells (NPCs). Poster at Stem Cells: The Next Generation, an ISSCR International Symposium, 10-12 November, 2017; Guangzhou, China; Poster Number: 018 (poster presentation)

Dinnyes ANeuronal differentiation of human pluripotent stem cells lines. Development of human immortalized and induced pluripotent stem cells for in vitro disease modelling and toxicity testing, EUTOXRISK, Sept 10-13 2017, Bratislava, Slovakia (oral presentation)

Kobolak J., Dinnyes A. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells (NPCS) from human iPSCs. A Magyar Kísérletes és Klinikai Farmakológiai Társaság Gyógyszerinnovációs Kongresszusa07.-09.May 2017, Velence, Hungary (poster presentation). 

Dinnyes, A. Kobolak, J. Idegrendszeri betegség és toxicitási modellek fejlesztése pluripotens őssejtek segítségével. Bio-Science Kft. Tudományos Napja, 03.May 2017, Budapest, Hunagry- Larus Rendezvényközpont. (oral presentation)

Chandrasekaran A, Avci H, Ochalek A, Molnár K, Laszlo L, Bellak T, Pesti K, Mike A, Kobolak J and Dinnyes A. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells (NPCS) from human iPSCs. Hungarian Molecular Life Sciences 2017, March 31-Apr 2, 2017, Hotel Eger & Park, Hungary (poster presentation)

Chandrasekaran A., Avci H., Ochalek A., Molnar K., Laszlo L., Bellak T., Pesti K., Mike A.,

Dinnyes, AGenetic reprogramming in cloning and stem cells: what we can learn for Assisted Reproduction?Sichuan University, Chengdu Sichuan University, 22 March 2017. Chengdu, China(oral presentation)

2016

Schmid BModelling Neurodegenerative Diseases Using iPS Cells. EBiSC course 23 November 2016, Edinburgh, Scotland. (oral presentation)

Schmid B, Holst B, Nimsanor N, Rasmussen MA, Bekker-Poulsen U, Jørring I, Stummann TC and Clausen C. Gene-editing technologies allow for the generation of precisely inserted gene cassettes with adjustable expression. DASCS 2016, 10. – 11. November 2016, Rungsted, Denmark. (abstract)

Pires C, Poon A, Schmid B, Nielsen TT, Hjermind LE, Nielsen JE, Clausen C, Hyttel P, Holst B and Freude KK. Role of PSEN1 in neuronal differentiation and Alzheimer’s disease – modeling human neurodegenerative diseases in a dish. 10th FENS Forum for Neuroscience, 2-6 July, 2016, Copenhagen, Denmark. (abstract)

Schmid BCRISPRs Technology. Summer Course at KU, 03 June 2016, Denmark. (oral presentation)

Aldana BI,Zhang Y, Bak LK, Nielsen JE, Holst B, Hyttel P, Freude KK, Waagepetersen H. Neurons derived from human induced pluripotent stem cells as tools for characterizing metabolic pathways in the human brain. 12th International Conference on Brain Energy Metabolism, 25-28 Maj 2016, Hong Kong. (abstract)

Schmid BModelling Neurodegenerative Diseases Using iPS Cells. EBiSC course 24 May 2016, Edinburgh, Scotland.  (oral presentation)

Pires C, Poon A, Schmid B, Nielsen TT, . Hjermind LE, Nielsen JE, Clausen C, Hyttel P, Holst B, Freude KK. Role of PSEN1 in neuronal differentiation and Alzheimer’s disease – modeling human neurodegeneration in a dish. CRISPR genome editing: From high-throughput screening to disease models. Panum, Copenhagen, 21-22 may 2016. (abstract) 

Schmid B. Progress on Apoɛ editing. EBiSC General Assembly Meeting No. 3, 7-8 April 2016, Berlin, Germany (oral presentation)

Holst BCatalyzing Company Development by Exploiting Stem Cell Research Services and Technologies Developed Through Public Private Partnerships – A Danish Perspective, ISRASTEM, 5-6 April 2016, Tel Aviv, Israel (oral presentation)

Holst B,Schmid B, Rasmussen MA, Clausen C and Pedersen LH. Reprogramming of Human Somatic Cells into Pluripotent Stem Cells (iPSC) and Gene-editing to build disease specific in vitro models. ISRASTEM, 5-6 April 2016, Tel Aviv, Israel. (abstract)

Schmid BGenome editing in iPS cells using the CRISPRs/Cas9 system for disease modeling. Tom Wahlig Symposium, 19 March 2016, Düsseldorf, Germany. (oral presentation)

Pires, C., Turnbull, H., Tubsuwan, A., Freude, K., Nielsen, J., Holst, B., Hyttel, P., Hall, V.J. Pertibation of nucleolar activity in neural progenitors and neurons derived from Alzheimer’s disease patients carrying PSEN1 mutations. Stem Cell Models of Neural Regeneration and Disease, 1-3 februar, 2016, Dresden, Germany. (abstract)

Schmid B, B Holst, A Tubsuwan, MA Rasmussen, TT Nielsen, K Freude, A Marthaler, Y Zhang, P Hyttel, U Bekker-Poulsen, JE Nielsen, and C Clausen. Modelling neurodegenerative diseases based on isogenic gene-corrected iPS cells. Stem Cell Models of Neural Regeneration and Disease, 1-3 februar, 2016, Dresden, Germany. (abstract)

Ochalek A., Bellak T., Chandrasekaran A., Szegedi V., Schmidt B., Bock I., Varga E., Nemes Cs., Zhou S., Hyttel P., Kobolak J., Dinnyes A., Avci H. ENGINEERING HIGH AND LOW COMPLEX 3D NEURAL TISSUE FROM HUMAN INDUCED PLURIPOTENT STEM CELLS. Stem Cell Models of Neural Regeneration and Disease (ISCCS meeting), 1-3 february, 2016, Dresden, Germany. (poster presentation) 

Zhang Y, Schmid B, Nanett K. Nikolaisen, Rasmussen MA, Nielsen TT, Callø K, Stummann TC, Larsen HM, Garcia BIA, Bak LK, Waagepetersen HS, Nielsen JE, Holst B, Clausen C, Hyttel P, Freude KK. Disease modeling of FTD with patient iPSC derived neurons and their isogenic controls. Stem Cell Models of Neural Regeneration and Disease, 1-3 februar, 2016, Dresden, Germany. (abstract)

Francz B., Schmidt B., Ochalek A., Chandrasekaran A., Avci H., Varga E., Kovács E., Kobolak J., Dinnyes A. Induced Pluripotent Stem cell-based in vitro neurotoxicology models. Paper presented at the HunDoc 2016, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, 20 January 2016, Budapest, Hungary. (poster presentation)

2015

Dinnyes, ASzemélyre szabott őssejtek“ − hogyan lehet bőr vagy vérmintából őssejteket, majd ideg- szív- és más sejttípusokat, szöveteket létrehozni emberben és állatokban. A Szent István Egyetem Állatorvos-tudományi Karának Baráti Köre, Szent István Egyetem, Molekuláris Állatbiotechnológiai Laboratórium, Hungary. 9 September, 2015 (oral presentation)

Bellak, T., Ochalek, A., Chandrasekaran, A., Szegedi, V., Avci, H., Szczesna, K., Varga, E., Nemes, Cs., Nogradi, A., Kobolak, J., Dinnyes, A. Modelling Alzheimer’s Disease with three-dimensional engineered neural tissue. A MAGYAR ANATÓMUS TÁRSASÁG XIX. KONGRESSZUSA, 11-13 June, 2015, Szeged, Hungary p:39. (poster presentation) 

Dinnyes A, Ochalek A, Chandrasekaran A, Bellák T, Szegedi V, Varga E, Zhou S, Teglasi A, Kovacs E, Szczesna K, Schmidt B, Avci H, Hyttel P, Kobolak J. Modelling the early developing central nervous system by 3D engineered neural tissue from human induced pluripotent stem cells. Epigenetics and Periconception Environment, Dubrovnik, Croatia. 26-29 April 2015 (abstract)

Dinnyes A., Ochalek A., Chandrasekaran A., Bellak T., Szegedi V., Varga E., Zhou S., Teglasi A., Kovacs E., Szczesna K., Schmidt B., Avci H., Hyttel P., Kobolak J. Modelling the developing CNS by 3D engineered neural tissue from human iPSC; Epigenetics and Periconception Environment, Dubrovnik, Croatia. 26-29, April, 2015 p:18. (oral presentation) 

Szczesna K., Zhou S., Avci H., Kobolak J., Varga E., Schmidt B., Ochalek A., Freude K., Cirea S., Hyttel P., Dinnyes A. Role of BFGF and EGF in neural rosette formation. Paper presented at the Hungarian Molecular Life Sciences 2015., 27-29, March, 2015, Eger, Hungary. (poster presentation)

Kobolak J, Chandrasekaran A., Ochalek A., Bellak T., Szegedi V., Varga E., Avci H., Zhou S., Szczesna K., Schmidt B., Dinnyes A. Patient specific induced pluripotent stem cells(IPSCS) and their neuronal differentiation in Alzheimer's disease. Hungarian Molecular Life Sciences 2015. 27-29, March, 2015, Hungary. P:108. (oral presentation)

Bellak T, Chandrasekaran A., Ochalek A., Szegedi V., Varga E., Nemes Cs., Zhou S., Avci H., Kobolak J., Dinnyes A.  3D engineered neural tissue from human induced pluripotent stem cells. Hungarian Molecular Life Sciences 2015. 27-29, March, 2015, Hungary. p:11, (abstract)

Bellak, T., Chandrasekaran, A., Ochalek, A., Szegedi, V., Varga, E., Nemes, C., Dinnyes, A. 3D engineered neural tissue from human induced pluripotent stem cells. Hungarian Molecular Life Sciences 2015, 27-29 March 2015 Eger, Hungary pp:252-253. (abstract)

Dinnyes, A., Chandrasekaran, A., Ochalek, A., Bellak, T., Szegedi, V., Avci, H., Varga, E., Teglasi, A., Kovacs, E., Szczesna, K., Schmidt, B., Kobolak, J. Betegspecifikus őssejtek differenciációja neurális és kardiális irányokba.A Magyar Kísérletes és Klinikai Farmakológiai Társaság Experimentális Farmakológiai Szekciójának IX. Szimpoziuma, 26-28. March 2015, Velence, Hungary. (oral presentation)

Dinnyes, A, Chandrasekaran A., Ochalek A., Tamas B., Sz. Viktor, Avci H., V.  Eszter, T. Annamária, K. Eszter,Szczesna K., Schmidt B., Kobolak J. Betegspecifikus őssejtek differenciójának neurális és kardiális irányokba.Hungarian experimental and clinical pharmacological company's experimental pharmacological IX. Symposium. 26-28.March 2015, Hungary. p:41. (oral presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Nemes, C., Varga, E., Bock, I., Zhou, S., Kobolak, J. Neuronal differentiation of human patient specific induced pluripotent stem cells. GlowBrain III. Workshop, Visualisation of molecular markers in the brain, 29-31 January 2015, Zagreb, Croatia. (oral presentation)

Bellak, T., Chandrasekaran, A., Ochalek, A., Szegedi, V., Zhou, S., Avci, H., Dinnyes, A. 3D engineered neural tissue from human induced pluripotent stem cells. XV. Biannual Conference of the Hungarian Neuroscience Society, 22-23 January 2015, p: 11, Budapest, Hungary. (abstract)

Chandrasekaran, A., Roesingh, LN., Ochalek, A., Nemes, C., Varga, E., Bock, I., Dinnyes, A. Comparison of 2D and 3D neuronal differentiation of patient specific induced pluripotent stem cells. XV. Biannual Conference of the Hungarian Neuroscience Society Hungarian Academy of Sciences, 22-23 January 2015. Budapest, Hungary, p:44 (poster presentation)

2014

Kobolak, J. Indukált pluripotens őssejt alapú betegség- modell létrehozása a központi idegrendszert érintő betegségekben. MBK Napok, 2014, 11-12 December 2014.  Gödöllő, Hungary. (oral presentation)

Kitiyanant, N., Phanthong, P., Promthem, K., Hongeng, S., Kitiyanant, Y. Generation and characterization of non-integrating human induced pluripotent stem cells from trisomy 21 human fetal fibroblasts. Regional Forum Series 2014, "Global controls in stem cells", organized by International Society for Stem Cell Research and Stem Cell Society Singapore, 5-7 November 2014, Singapore. (poster presentation)

Kaveh Mashayekhi: Invited guest lecture: Presentation title “Genomics and Bioinformatics in Disease Biomarker Discovery”. University of Vet Medic Hannover. 5 November 2014. University of Veterinary Medicine Hannover (TiHo) Bünteweg 2, 30559 Hannover, Germany. (oral presentation)

Dinnyes ANeuronal differentiation of patient specific induced pluripotent stem cells. Stem cells in cancer and regenerative medicine EMBO Conference, 9–12 October 2014, Heidelberg, Germany. (poster presentation)

Chandrasekaran, A., Roesingh, LN., Nemes, Cs., Varga, E., Bock, I., Zhou, S., Kobolak, J. Induced ploripotent stem cells for biomedical applications. Paper presented at the Innovations in Medicine, 10. October 2014, Budapest, Hungary.p:5 (oral presentation)

Dinnyes, APatient specific induced pluripotent stem cells and their neuronal differentiation. Annual Meeting of the Hungarian Biochemical Society. 2014. 25 August, 2014. Debrecen, Hungary .p:16. (oral presentation)

Chandrasekaran, A.,Neelchen Roesingh, L., Nemes, C., Varga, E., Bock, I., Zhou, S., Kobolak, J. Patient specific induced pluripotent stem cells and their neuronal differentiation. Annual Meeting of the Hungarian Biochemical Society, 24-27. August 2014, Debrecen, Hungary.p:16 (oral presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Ochalek, A., Nemes, Cs., Varga, E., Bock, I., Kobolak, J. Neuronal differentiation from human induced pluripotent stem cells. IDPbyNMR Final meeting, 21-26. September 2014 Grosseto, Italy. (abstract)

Kitiyanant, NDevelopment of Induced Pluripotent Stem Cells (IPSCs) and transdifferentiation into neural stem cells for brain aging and Alzheimer's disease in

"Development of Research Strategies for Brain, Mind and Behavior Meeting", organized by National Research Council of Thailand and Health Systems Research Institute, 21-23 July 2014, Bangkok, Thailand. (oral presentation)

Dinnyes, ABest practice example: BioTalentum Ltd supported by FP6/7 Stem Cell Research Towards Patient Specific Treatments in V4 Workshop. 1. July 2014. Brussels, Belgium. (oral presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Berzsenyi, S., Kobolak, J., & Dinnyes, A. Small molecule induced neuronal differentiation of hIPS cell lines through NPC derivation. Paper presented at the Fiatal Biotechnológusok Országos Konferenciája (FIBOK 2014), 7 March 2014, Szeged, Hungary. p:46 (poster presentation)

Pajer, K., Nemes, Cs., Berzsenyi, S., Nogradi, A., Dinnyes, A. Grafted mouse iPS cells rescue injured rat motoneurons following ventral root avulsion. 1st. Innovation in Science 2014 - Doctoral Student Conference, 2-3 May, 2014, Szeged, Hungary. (abstract)

Dinnyes, A., Berzsenyi, S., Varga, E., Nemes, Cs., & Kobolak, J. ESCs and iPSCs to Generate 2D and 3D Neural Structures for Drug Discovery and Toxicity Testing. 9th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies, 30-31 January 2014, Brussels, Belgium. (oral presentation)

2013

Dinnyes, A., Berzsenyi, S., Nemes, C., Varga, E., & Kobolak, J. Emberi indukált pluripotens őssejtek az idegrendszeri és más örökletes betegségek kutatásának szolgálatában. Transzlációs klinikai idegtudományok: az omikától a proteomikáig, 6-7. December 2013, Velence, Hungary. (oral presentation)

Dinnyes, A2D and 3D neural structures generated from pluripotent stem cells in mouse and human. Paper presented at the Manchester Tissue Regeneration and Stem Cell Network Seminar Series 2013/2014, 8. November 2013, Manchester, UK. (oral presentation)

Kitiyanant, N. Lessons Learned/Best Practices: FP7 in "Thailand's Participation in FP7: A Review", organized by National Science and Technology Development Agency, 8 Nov 2013, Bangkok, Thailand (oral presentation)

Dinnyes, A., Varga, E., & Berzsenyi, S. Betegspecifikus őssejtek, majd idegsejtek előállítása bőr és vér minták genetikai újraprogramozásával. Magyar Tudományos Parkinson Társaság konferenciája, Budapest, Hungary. 31. May - 1. June 2013. pp:1-3 (oral presentation)

 

Outreach activities

2018

Freude KK: Implications of CRISPR-Cas9 gene editing in iPSC models for neurodegenerative diseases. Copenhagen Bioscience Cluster, 5 April 2018, Copenhagen, Denmark.

Hyttel P: Demens i en petriskål - og andre perspektiver af stamceller. Foreningen af biologi-bioteknologi studerende (FB), Københavns Universitet, 22 March 2018,Copenhagen, Denmark.

Hyttel P: Demens i en petriskål - og andre perspektiver af stamceller. Asminderød sognegård, 21 March 2018, Fredensborg, Denmark.

Hyttel P: Stamceller – muligheder og risici. Meeting for Veterinary Practitioners, Salfarm Danmark A/S, Hotel Kolding Fjord, 21 March 2018, Kolding, Denmark.

Hyttel P, Interview for DR2-Dagen regarding development of human organs in sheep (26 February 2018).

Hyttel P: Rugemor havde menneskefår i maven. Interview for Politiken (25 February 2018).

Hyttel P, Interview for P1 (“Hjernekassen”, Peter Lund Madsen) regarding stem cells (19 February 2018).

Hyttel P: Er menneskegrise dyr eller mennesker? Interview for Videnskab.dk (5 February 2018).

Hyttel P: Interview for Videnskab.dk regarding stem cells and cloning of monkeys (24 January 2018).

Hyttel P: Interview for TV2 News regarding stem cells and cloning of monkeys (24 January 2018).

Hyttel P: Interview for TV2 regarding stem cells and cloning of monkeys (24 January 2018).

Hyttel P: Interview for Radio24syv regarding stem cells and cloning (22 January 2018).

2017

Hyttel P: Invited talk: Why is it important to think in terms of impact and how do you communicate a project. DFF Seminar for Sapere Aude: DFF-Starting Grant holders, 22 November 2017, Copenhagen, Denmark. Participating: Professor (MSO) David Budtz Pedersen, Professor Poul Hyttel, and Professor Lotte Bøgh Andersen. Moderated by: Professor Jane Hvolbæk Nielsen, board member, Independent Research Fund Denmark.

Freude KK: Modelling Neurodegenerative Diseases in a Dish with the help of CRISPR-Cas9.CRISPR & Precision Genome Editing Europe 2017, 13-15 November 2017, Berlin, Germany.

Hyttel P: Induced pluripotent stem cells for modelling and treatment of neurodegeneration. Lecture on course on “Celleterapi”, Rigshospitalet, 8 November 2017, Copenhagen, Denmark.

Kitiyanant N. Invited talk: International Research Grant Success Stories: Marie Sklowdowska-Curie Actions (MSCA). International Grant Proposal Writing Workshop, Khon Kaen University, 4 July 2017, Khon Kaew, Thailand.

Freude KK: Stem Cell Symposium, UC Irvine, https://www.bio.uci.edu/2017/10/regenerative-medicine/ USA July 2017

Hyttel P: Dementia in a dish – induced pluripotent stem cell-modeling of neurodegeneration. Scand-Las, 28 June 2017, Copenhagen, Denmark.

Freude KK: Cellular phenotypes of AD iPSC derived neurons. Danish Society for Neuroscience, May 8-9 2017, Nyborg, Denmark.

Hyttel P: Induced pluripotent stem cells for modeling and treatment of neurodegeneration. PhD Days, Doctoral School in Science and Engineering (DSSE), University of Luxembourg 2017, Luxembourg.

2016

Hyttel P: Invited opening Lecture: Dementia in a dish – induced pluripotent stem cell-modeling of neurodegeneration. Danish Stem Cell Society (DASCS), 10 November 2016, Rungstedgård, Rungsted, Denmark.

Hyttel P: How do animal and human biomedicine benefit from each other? SEARMET meeting, Universit of Tartu, 17-19 October 2016, Tartu, Estonia.

Hyttel P: Dementia in a dish – prospects of human induced pluripotent stem cells.Research Inspiration Day, University Hospital for Companion Animals, 25 August 2016, Copenhagen, Denmark.

2015

Freude KK: “The Hope and Hypes of Stem Cells” Kort Sagt, Central Copenhagen library. Available online: https://www.youtube.com/watch?v=b5wp-WNn9EE. October 2015, Copenhagen, Denmark.

Hyttel P: Invited lecture: Induced pluripotent stem cell reprogramming and neurodegeneration. Biotalentum 10th Anniversary Scientific Workshop and ANISTEM Project Final Workshop, 29 September 2015, Budapest, Hungary.

Freude KK: In vitro models for FTD3. Danish Society for Neuroscience, 11-12 May 2015, Nyborg, Denmark.

Hyttel P: Invited lectures: (1) Development mechanisms to obtain bovine embryos and pig oocytes: cellular and molecular aspects, (2) General aspects of epigenetic control and early embryonic development, (3) Pluripotent and embryonic  stem cells and (4) Human pluripotent stem cells: reprogramming and differentiation to neural cell therapies. Postgraduation program in Anatomy of Domestic and Sylvester Animals, Department of Surgery, Sector of Anatomy, School of Veterinary Medicine and Animal Science, University of São Paulo, 2015, São Paulo, Brazil.

2014

Hyttel P:Stamceller som model for demenssygdomme: Kan vi skabe kunstige syge hjerner? Conference: Demensforskning anno 2014, 28 November 2014, Nationalt Videncenter for Demens. Rigshospitalet, Copenhagen, Denmark

Freude KK: Stem cell models of neurodegenerative diseases. DIS, 3 September 2014, Copenhagen, Denmark.

Kitiyanant N. International Research Grant Success Stories: Marie Sklowdowska-Curie Actions (MSCA) in "International Grant Proposal Writing Workshop", organized by Khon Kaen University, 4 July 2017, Khon Kaew, Thailand. (invited talk)

Kaveh Mashayekhi: Invited talk: Computational and Systems Biology, way to the target.Research Institute of Biological Psychiatry, Sct. Hans Hospital, 9 May 2014, Roskilde, Denmark

Hyttel P: Establishment of patient-specific induced pluripotent stem cell (iPSC) lines for neurodegenerative modeling. ICMM Annual Meeting 2014, LO-skolen, Helsingør, Denmark.

2013

Dinnyés A, Director of Biotalentum Kft: Országos Diákkonferencia. 16 July 2013. Káptalanfüred, Hungary. (Invited talk).