Publications

Chandrasekaran, A, Avci, HX, Ochalek, A, Rösingh, LN, Molnár, K, László, L, Bellák, T, Téglási, A, Pesti, K, Mike, A, Phanthong, Hall, V, Kitiyanant, N, Krause, KH, Kobolák, J and Dinnyés A. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human iPSCs. Stem Cell Research; Accepted date: 10 October 2017; doi:10.1016/j.scr.2017.10.010

Ochalek, A; Mihalik, B; Avci, HA; Chandrasekaran, A; Téglási, A; Bock, I; Giudice, ML; Táncos, Z; Molnár, K; László, L; Nielsen, JE; Holst, B; Freude, K; Hyttel, P; Kobolák, J; Dinnyes, A. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels and GSK3B activation. Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z

Zhang Y., Schmid B, Nikolaisen N.K., Rasmussen M.A., Aldana B.I., Agger M., Calloe K., Stummann T.C., Larsen H.M, Nielsen T.T, Huang J., Xu F., Liu X., Bolund L., Meyer M., Bak L.K., Waagepetersen H.S., Luo Y., Nielsen J.E., The FReJA Consortium, Holst B., Clausen C., Hyttel P. and Freude K.K. Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Stem Cell Reports, 8(3), 1-11, 2017. doi: 10.1016/j.stemcr.2017.01.012.

Tangprasittipap A, Jittorntrum B, Wongkummool W, Kitiyanant N, Tubsuwan A. Generation of induced pluripotent stem cells from peripheral blood CD34+ hematopoietic progenitors of a 31-year-old healthy woman. Stem Cell Res. 2017 Apr;20:91-93. doi: 10.1016/j.scr.2017.02.013. 

Wongkummool W, Maneepitasut W, Munkongdee T, Tong-Ngam P, Tangprasittipap A, Svasti S, Kitiyanant N, Paiboonsukwong K, Fucharoen S, Tubsuwan A. Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring. Stem Cell Res. 2017 Apr;20:84-87. doi: 10.1016/j.scr.2017.02.014. 

Wongkummool W, Maneepitasut W, Tong-Ngam P, Tangprasittipap A, Munkongdee T, Boonchuay C, Svasti S, Kitiyanant N, Paiboonsukwong K, Fucharoen S, Tubsuwan A. Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2. Stem Cell Res. 2017 Apr;20:80-83. doi: 10.1016/j.scr.2017.02.012. 

Secher, J.O., Ceylan, A., Mazzoni, G., Mashayekhi, K., Li, T., Muenthaisong, S., Nielsen, T.T.,  Li, D., Li, S., Petkov, S., Cirera, S.,  Luo, Y.,Thombs, L., Kadarmideen, H., N.,  Dinnyes, A., Bolund, L., Roelen , B. A. J., Schmidt, M., Callesen, H.,  Hyttel, P.,  Freude, K.K Systematic in Vitro and in Vivo Characterization of Leukemia-Inhibiting Factor- And Fibroblast Growth Factor-Derived Porcine Induced Pluripotent Stem Cells. Molecular Reproduction & Development, 3 January 2017, 84(3), pp: 229-245. doi: 10.1002/mrd.22771

Poon A, Zhang Y, Chandrasekaran A, Phanthong P, Schmid B, Nielsen TT, Freude KK. Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges. N Biotechnol. 2017 Jun 2. pii: S1871-6784(16)32499-2. doi: 10.1016/j.nbt.2017.05.009.

Phathong, P., Borwornpinyo, S., Kitiyanant, N., Jearawiriyapaisarn, N., Nunzakarn, L., Saetan, J. Nualkaew, T. Sa-Ngiamsuntorn, K., Anurathapan, U., Dinnyes, A.,Kitiyanant, Y., Hongeng, S. . (2017). Enhancement of b-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Stem Cells Tranlational Medicine. 18 February 2017, 6(4) pp:1059-1069 doi: 10.1002/sctm.16-0121.

Nagy J, Kobolák J, Berzsenyi S, Ábrahám Z, Avci H X, Bock I,Bekes Z,Hodoscsek B,Chandrasekaran A,Téglási A, Dezső P,Koványi B,Vörös E T,Fodor L,Szél T, Németh K, Balázs A,Dinnyés A, Lendvai B,Lévay G,Román V. Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism. Translational Psychiatry  2017  July 25, 7, e1179; doi:10.1038/tp.2017.144

Nimsanor, N., Jørring, I., Rasmussen, M.A., Clausen, C., Mau-Holzmannb U.A., Bus C., Hoffmann, S.A., Gasser, T., Kluba, T., Holst, B. and Schmid, B.: Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases. Stem Cell Research 17(3): 550-552, 2016. doi:10.1016/j.scr.2016.09.019

Nimsanor, N., Kitiyanant, N., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research 17(3): 556-559, 2016. doi:10.1016/j.scr.2016.09.021

Nimsanor, N., Jørring, I., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Kitiyanant, N., Nielsen, J.E., Nielsen, T.T. Hyttel, P., Holst, B. and Schmid, B.: Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Stem Cell Research 17(3): 564-567, 2016. doi:10.1016/j.scr.2016.10.006

Nimsanor, M., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research 17(3): 576-579, 2016 doi: 10.1016/j.scr.2016.09.020

Nimsanor, M., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line derived from a pre-symptomatic 28-year-old female patient with frontotemporal dementia caused by a R406W mutation in microtubule associated protein tau (MAPT). Stem Cell Research 17(3): 600-602, 2016. doi:10.1016/j.scr.2016.09.024

Pires C, Schmid B, Petræus C, Poon A, Nimsanor N, Nielsen TT, Waldemar G, Hjermind LE, Nielsen J, Hyttel P and Freude KK. Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1. Stem cell Research 17 285-288, 2016. doi:10.1016/j.scr.2016.08.002

Rungarunlert, S. J. N.. Ferreira, A., Dinnyes. Novel Bioreactor Platform for Scalable Cardiomyogenic Differentiation from Pluripotent Stem Cell-Derived Embryoid Bodies Methods in Molecular Biology, Bioreactors in Stem Cell Biology 5 April 2016, 1502 pp:169-179 doi: 10.1007/7651_2016_341

Poon A, Li T, Pires C, Nielsen TT, Nielsen JE, Holst B, Dinnyes A, Hyttel P, Freude KK. Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1. Stem Cell Res. 2016 Nov;17(3):470-473. doi: 10.1016/j.scr.2016.09.016.

Poon A, Schmid B, Pires C, Nielsen TT, Hjermind LE, Nielsen JE, Holst B, Hyttel P, Freude KK. Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1. Stem Cell Res. 2016 Nov;17(3):466-469. doi: 10.1016/j.scr.2016.09.018.

Pires C, Hall V and Freude KK. Human Induced Pluripotent Stem Cells and their Derivatives for Disease Modeling and Therapeutic Applications in Alzheimer’s Disease. Alzheimer's disease. SMGroup, 2016. p. 1-25.

Schmidt BZ, M. Lehmann, S. Gutbier, E. Nembo,S. Noel,  L. Smirnova, A. Forsby,J.  Hescheler, H. X. Avci, T.  Hartung,  M. Leist,  J. Kobolák, A. Dinnyés. In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high‑throughput technical possibilities. Archives of Toxicology, 04 August 2016, 91(1), pp: 1-33. doi: 10.1007/s00204-016-1805-9

Secher JO, Callesen H, Freude KK, Hyttel P. Initial embryology and pluripotent stem cells in the pig—The quest for establishing the pig as a model for cell therapy. Theriogenology. 2016 Jan 1;85(1):162-71. doi: 10.1016/j.theriogenology.2015.09.017.

Ochalek A, K. Szczesna, P. Petazzi,J. Kobolak,A. Dinnyes. (2016). Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy. Stem Cells International, 26 December 2016, 2016, pp: 1-16. doi: 10.1155/2016/5838934.

Chandrasekaran, A., Avci, H.X., Leist, M., Kobolák, J., Dinnyés, A. Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research. Frontiers in Cellular Neuroscience, 26 September 2016, 10(215), pp: 1-27. doi: 10.3389/fncel.2016.00215

Hansen S.K., Borland H., Hasholt L.F., Tümer Z., Nielsen J.E., Rasmussen M.A., Nielsen T.T., Stummann T.C., Fog K. and Hyttel P.: Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11. Stem Cell Res. 2016 May;16(3):553-6. doi: 10.1016/j.scr.2016.02.040

Hansen SK, Stummann TC, Borland H, Hasholt LF, Tümer Z, Nielsen JE, Rasmussen MA, Nielsen TT, Daechsel JC, Fog K, Hyttel P. Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. Stem Cell Res. 2016 Sep;17(2):306-317. doi: 10.1016/j.scr.2016.07.004.

Hansen S.K., Borland H., Hasholt L.F., Tümer Z., Nielsen J.E., Rasmussen M.A., Nielsen T.T., Stummann T.C., Fog K. and Hyttel P.: Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11. Stem Cell Res. 2016 May;16(3):589-92.

Li T., Pires C., Nielsen T.T., Waldemar G., Hjermind L.E., Nielsen J.E., Dinnyes A., Holst B., Hyttel P. and Freude K.K. Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1. Stem Cell Research 2016, 16(2):334-337.

Li T., Pires C., Nielsen T.T., Waldemar G., Hjermind L.E., Nielsen J.E., Dinnyes A., Hyttel P. and Freude K.K.: Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1. Stem Cell Research 2016, 16(2):229-232. doi: 10.1016/j.scr.2016.01.002.

Zhou S., Ochalek A., Szczesna K., Avci H.X., Kobolák J., Varga E., Rasmussen M., Holst B., Cirera S., Hyttel P., Freude K.K. and Dinnyés A.: The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF. Differentiation.  2016 Jun 16. doi: 10.1016/j.diff.2016.06.002. [Epub ahead of print]

Zhang Y., Schmid B., Nielsen T.T., Nielsen. J.E., Clausen C., Hyttel P., Holst B. and Freude K.K.: Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B. Stem Cell Research 17(1): 148-150, 2016.

Zhang Y., Schmid B., Nielsen T.T., Nielsen. J.E., Clausen C., Hyttel P., Holst B. and Freude K.K.: Generation of a human induced pluripotent stem cell line viaCRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B. Stem Cell Research 17(1): 151-153, 2016.

Nemes C., Varga E., Táncos Z., Bock I., Francz B., Kobolák J. and Dinnyés A.: Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient. Stem Cell Research 17(1): 69-71, 2016.

Ochalek A., Nemes C., Varga E., Táncos Z., Kobolák J. and Dinnyés A.: Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 72-74, 2016.

Táncos Z., Varga E., Kovács E., Dinnyés A. and Kobolák K.: Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 75-77, 2016.

Chandrasekaran A., Varga E., Nemes C., Táncos Z., Kobolák J. and Dinnyés A.: Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 78-80, 2016.

Táncos Z., Varga E., Kovács E., Dinnyés A. and Kobolák J.: Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 81-83, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1): 70-74, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1): 75-78, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia. Stem Cell Research, 16(1): 105-109, 2016.

Tubsuwan A., Pires C., Rasmussen M.A., Schmid B., Nielsen J.E., Hjermind L.E., Hall V., Nielsen T.T., Waldermar G., Hyttel P., Clausen C., Kitiyanant N., Freude K.K. and Holst B.: Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer’s disease patient carrying a L150P mutation in PSEN-1. Stem Cell Research, 16(1): 110-112, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem Cell Research, 16(1): 159-161, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem Cell Research, 16(1): 162-165, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen, J.E. and Holst B.: Generation of Spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research, 16(1): 166-169, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem Cell Research, 16(1): 180-183, 2016
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Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem Cell Research, 16(1): 199-201, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research, 16(1): 202-205, 2016.

Pajera K, Cs. Nemes, S. Berzsenyi, K. A. Kovács, M. K. Pirity, G. Pajendac, A. Nógrádia, A., Dinnyés. Grafted murine induced pluripotent stem cells prevent death of injured rat motoneurons otherwise destined to die. Experimental Neurology,16 May 2015, 269, pp: 188-201. doi: 10.1016/j.expneurol.2015.03.031

Hall VJ, Lindblad MM, Jakobsen JE, Gunnarsson A, Schmidt M, Rasmussen MA, Volke D, Zuchner T, Hyttel P. Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Dis Model Mech. 2015 Oct 1;8(10):1265-78. doi: 10.1242/dmm.019489.

Tangprasittipap A, Satirapod C, Jittorntrum B, Lertritanan S, Anurathaphan U, Phanthong P, Borwornpinyo S, Kitiyanant N, Hongeng S. Tangprasittipap A., Satirapod C, Jittorntrum B, Lertritanan S, Anurathaphan U, Phanthong P, Borwornpinyo S, Kitiyanant N, Hongeng S. Generation of iPSC line MU011.A-hiPS from homozygous α-thalassemia fetal skin fibroblasts. Stem Cell Res. 2015 Nov;15(3):506-9. doi: 10.1016/j.scr.2015.09.003.

Zhou S., Szczesna K., Ochalek A., Kobolák J., Varga E., Nemes C., Chandrasekaran A., Rasmussen M., Cirera S., Hyttel P., Dinnyés A., Freude K.K., and Avci H.X.: Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells International, Aug. 2015.

Høffding M.K., Hyttel P: Ultrastructural visualization of the Mesenchymal-to-Epithelial Transition during reprogramming of human fibroblasts to induced pluripotent stem cells. Stem CellResearch, Nov. 2014.

Varga E , Juhász G, Bozsó Z, Penke B, Fulop L, and Szegedi V: Abeta (1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors. Neural Plasticity, Sept. 2014.

Rasmussen M.R., Holst B., Tümer Z., Johnsen M.G., Zhou S., Stummann T.C., Hyttel P., and Clausen C.: Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage. Stem Cell Reports, Vol. 3, 404–413, September 9, 2014.

Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A: Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Exp Cell Res. 2014 Apr 1;322(2):335-44.

Nemes C, Varga E, Polgar Z, Klincumhom N, Pirity MK, Dinnyes A.: Generation of Mouse Induced Pluripotent Stem Cells by Protein Transduction. Tissue Eng Part C Methods, 2013 Oct 12. Epub 2013 Oct 10.

Phanthong P, Raveh-Amit H, Li T, Kitiyanant Y, Dinnyes A.: Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells. Biogerontology, 2013 Dec;14(6):591-602. doi: 10.1007/s10522-013-9455-2. Epub 2013 Aug 21.