Publications

Peer Reviewed Journals

Chandrasekaran, A, Avci, HX, Ochalek, A, Rösingh, LN, Molnár, K, László, L, Bellák, T, Téglási, A, Pesti, K, Mike, A, Phanthong, Hall, V, Kitiyanant, N, Krause, KH, Kobolák, J and Dinnyés A. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human iPSCs. Stem Cell Research; Accepted date: 10 October 2017; doi:10.1016/j.scr.2017.10.010

Ochalek, A; Mihalik, B; Avci, HA; Chandrasekaran, A; Téglási, A; Bock, I; Giudice, ML; Táncos, Z; Molnár, K; László, L; Nielsen, JE; Holst, B; Freude, K; Hyttel, P; Kobolák, J; Dinnyes, A. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels and GSK3B activation. Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z

Zhang Y., Schmid B, Nikolaisen N.K., Rasmussen M.A., Aldana B.I., Agger M., Calloe K., Stummann T.C., Larsen H.M, Nielsen T.T, Huang J., Xu F., Liu X., Bolund L., Meyer M., Bak L.K., Waagepetersen H.S., Luo Y., Nielsen J.E., The FReJA Consortium, Holst B., Clausen C., Hyttel P. and Freude K.K. Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Stem Cell Reports, 8(3), 1-11, 2017. doi: 10.1016/j.stemcr.2017.01.012.

Tangprasittipap A, Jittorntrum B, Wongkummool W, Kitiyanant N, Tubsuwan A. Generation of induced pluripotent stem cells from peripheral blood CD34+ hematopoietic progenitors of a 31-year-old healthy woman. Stem Cell Res. 2017 Apr;20:91-93. doi: 10.1016/j.scr.2017.02.013. 

Wongkummool W, Maneepitasut W, Munkongdee T, Tong-Ngam P, Tangprasittipap A, Svasti S, Kitiyanant N, Paiboonsukwong K, Fucharoen S, Tubsuwan A. Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring. Stem Cell Res. 2017 Apr;20:84-87. doi: 10.1016/j.scr.2017.02.014. 

Wongkummool W, Maneepitasut W, Tong-Ngam P, Tangprasittipap A, Munkongdee T, Boonchuay C, Svasti S, Kitiyanant N, Paiboonsukwong K, Fucharoen S, Tubsuwan A. Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2. Stem Cell Res. 2017 Apr;20:80-83. doi: 10.1016/j.scr.2017.02.012. 

Secher, J.O., Ceylan, A., Mazzoni, G., Mashayekhi, K., Li, T., Muenthaisong, S., Nielsen, T.T.,  Li, D., Li, S., Petkov, S., Cirera, S.,  Luo, Y.,Thombs, L., Kadarmideen, H., N.,  Dinnyes, A., Bolund, L., Roelen , B. A. J., Schmidt, M., Callesen, H.,  Hyttel, P.,  Freude, K.K Systematic in Vitro and in Vivo Characterization of Leukemia-Inhibiting Factor- And Fibroblast Growth Factor-Derived Porcine Induced Pluripotent Stem Cells. Molecular Reproduction & Development, 3 January 2017, 84(3), pp: 229-245. doi: 10.1002/mrd.22771

Poon A, Zhang Y, Chandrasekaran A, Phanthong P, Schmid B, Nielsen TT, Freude KK. Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges. N Biotechnol. 2017 Jun 2. pii: S1871-6784(16)32499-2. doi: 10.1016/j.nbt.2017.05.009.

Phathong, P., Borwornpinyo, S., Kitiyanant, N., Jearawiriyapaisarn, N., Nunzakarn, L., Saetan, J. Nualkaew, T. Sa-Ngiamsuntorn, K., Anurathapan, U., Dinnyes, A.,Kitiyanant, Y., Hongeng, S. . (2017). Enhancement of b-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Stem Cells Tranlational Medicine. 18 February 2017, 6(4) pp:1059-1069 doi: 10.1002/sctm.16-0121.

Nagy J, Kobolák J, Berzsenyi S, Ábrahám Z, Avci H X, Bock I,Bekes Z,Hodoscsek B,Chandrasekaran A,Téglási A, Dezső P,Koványi B,Vörös E T,Fodor L,Szél T, Németh K, Balázs A,Dinnyés A, Lendvai B,Lévay G,Román V. Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism. Translational Psychiatry  2017  July 25, 7, e1179; doi:10.1038/tp.2017.144

Nimsanor, N., Jørring, I., Rasmussen, M.A., Clausen, C., Mau-Holzmannb U.A., Bus C., Hoffmann, S.A., Gasser, T., Kluba, T., Holst, B. and Schmid, B.: Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases. Stem Cell Research 17(3): 550-552, 2016. doi:10.1016/j.scr.2016.09.019

Nimsanor, N., Kitiyanant, N., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research 17(3): 556-559, 2016. doi:10.1016/j.scr.2016.09.021

Nimsanor, N., Jørring, I., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Kitiyanant, N., Nielsen, J.E., Nielsen, T.T. Hyttel, P., Holst, B. and Schmid, B.: Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Stem Cell Research 17(3): 564-567, 2016. doi:10.1016/j.scr.2016.10.006

Nimsanor, M., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research 17(3): 576-579, 2016 doi: 10.1016/j.scr.2016.09.020

Nimsanor, M., Poulsen, U., Rasmussen, M.A., Clausen, C., Mau-Holzmann, U.A., Nielsen, J.E., Nielsen, T.T., Hyttel, P., Holst, B. and Schmid, B.: Generation of an isogenic, gene-corrected iPSC line derived from a pre-symptomatic 28-year-old female patient with frontotemporal dementia caused by a R406W mutation in microtubule associated protein tau (MAPT). Stem Cell Research 17(3): 600-602, 2016. doi:10.1016/j.scr.2016.09.024

Pires C, Schmid B, Petræus C, Poon A, Nimsanor N, Nielsen TT, Waldemar G, Hjermind LE, Nielsen J, Hyttel P and Freude KK. Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1. Stem cell Research 17 285-288, 2016. doi:10.1016/j.scr.2016.08.002

Rungarunlert, S. J. N.. Ferreira, A., Dinnyes. Novel Bioreactor Platform for Scalable Cardiomyogenic Differentiation from Pluripotent Stem Cell-Derived Embryoid Bodies Methods in Molecular Biology, Bioreactors in Stem Cell Biology 5 April 2016, 1502 pp:169-179 doi: 10.1007/7651_2016_341

Poon A, Li T, Pires C, Nielsen TT, Nielsen JE, Holst B, Dinnyes A, Hyttel P, Freude KK. Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1. Stem Cell Res. 2016 Nov;17(3):470-473. doi: 10.1016/j.scr.2016.09.016.

Poon A, Schmid B, Pires C, Nielsen TT, Hjermind LE, Nielsen JE, Holst B, Hyttel P, Freude KK. Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1. Stem Cell Res. 2016 Nov;17(3):466-469. doi: 10.1016/j.scr.2016.09.018.

Pires C, Hall V and Freude KK. Human Induced Pluripotent Stem Cells and their Derivatives for Disease Modeling and Therapeutic Applications in Alzheimer’s Disease. Alzheimer's disease. SMGroup, 2016. p. 1-25.

Schmidt BZ, M. Lehmann, S. Gutbier, E. Nembo,S. Noel,  L. Smirnova, A. Forsby,J.  Hescheler, H. X. Avci, T.  Hartung,  M. Leist,  J. Kobolák, A. Dinnyés. In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high‑throughput technical possibilities. Archives of Toxicology, 04 August 2016, 91(1), pp: 1-33. doi: 10.1007/s00204-016-1805-9

Secher JO, Callesen H, Freude KK, Hyttel P. Initial embryology and pluripotent stem cells in the pig—The quest for establishing the pig as a model for cell therapy. Theriogenology. 2016 Jan 1;85(1):162-71. doi: 10.1016/j.theriogenology.2015.09.017.

Ochalek A, K. Szczesna, P. Petazzi,J. Kobolak,A. Dinnyes. (2016). Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy. Stem Cells International, 26 December 2016, 2016, pp: 1-16. doi: 10.1155/2016/5838934.

Chandrasekaran, A., Avci, H.X., Leist, M., Kobolák, J., Dinnyés, A. Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research. Frontiers in Cellular Neuroscience, 26 September 2016, 10(215), pp: 1-27. doi: 10.3389/fncel.2016.00215

Hansen S.K., Borland H., Hasholt L.F., Tümer Z., Nielsen J.E., Rasmussen M.A., Nielsen T.T., Stummann T.C., Fog K. and Hyttel P.: Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11. Stem Cell Res. 2016 May;16(3):553-6. doi: 10.1016/j.scr.2016.02.040

Hansen SK, Stummann TC, Borland H, Hasholt LF, Tümer Z, Nielsen JE, Rasmussen MA, Nielsen TT, Daechsel JC, Fog K, Hyttel P. Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. Stem Cell Res. 2016 Sep;17(2):306-317. doi: 10.1016/j.scr.2016.07.004.

Hansen S.K., Borland H., Hasholt L.F., Tümer Z., Nielsen J.E., Rasmussen M.A., Nielsen T.T., Stummann T.C., Fog K. and Hyttel P.: Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11. Stem Cell Res. 2016 May;16(3):589-92.

Li T., Pires C., Nielsen T.T., Waldemar G., Hjermind L.E., Nielsen J.E., Dinnyes A., Holst B., Hyttel P. and Freude K.K. Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1. Stem Cell Research 2016, 16(2):334-337.

Li T., Pires C., Nielsen T.T., Waldemar G., Hjermind L.E., Nielsen J.E., Dinnyes A., Hyttel P. and Freude K.K.: Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1. Stem Cell Research 2016, 16(2):229-232. doi: 10.1016/j.scr.2016.01.002.

Zhou S., Ochalek A., Szczesna K., Avci H.X., Kobolák J., Varga E., Rasmussen M., Holst B., Cirera S., Hyttel P., Freude K.K. and Dinnyés A.: The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF. Differentiation.  2016 Jun 16. doi: 10.1016/j.diff.2016.06.002. [Epub ahead of print]

Zhang Y., Schmid B., Nielsen T.T., Nielsen. J.E., Clausen C., Hyttel P., Holst B. and Freude K.K.: Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B. Stem Cell Research 17(1): 148-150, 2016.

Zhang Y., Schmid B., Nielsen T.T., Nielsen. J.E., Clausen C., Hyttel P., Holst B. and Freude K.K.: Generation of a human induced pluripotent stem cell line viaCRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B. Stem Cell Research 17(1): 151-153, 2016.

Nemes C., Varga E., Táncos Z., Bock I., Francz B., Kobolák J. and Dinnyés A.: Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient. Stem Cell Research 17(1): 69-71, 2016.

Ochalek A., Nemes C., Varga E., Táncos Z., Kobolák J. and Dinnyés A.: Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 72-74, 2016.

Táncos Z., Varga E., Kovács E., Dinnyés A. and Kobolák K.: Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 75-77, 2016.

Chandrasekaran A., Varga E., Nemes C., Táncos Z., Kobolák J. and Dinnyés A.: Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 78-80, 2016.

Táncos Z., Varga E., Kovács E., Dinnyés A. and Kobolák J.: Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Research 17(1): 81-83, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1): 70-74, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1): 75-78, 2016.

Rasmussen M.A., Hjermind L.E., Hasholt L.F., Waldemar G., Nielsen J.E., Clausen C., Hyttel P. and Holst B.: Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia. Stem Cell Research, 16(1): 105-109, 2016.

Tubsuwan A., Pires C., Rasmussen M.A., Schmid B., Nielsen J.E., Hjermind L.E., Hall V., Nielsen T.T., Waldermar G., Hyttel P., Clausen C., Kitiyanant N., Freude K.K. and Holst B.: Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer’s disease patient carrying a L150P mutation in PSEN-1. Stem Cell Research, 16(1): 110-112, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem Cell Research, 16(1): 159-161, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem Cell Research, 16(1): 162-165, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen, J.E. and Holst B.: Generation of Spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research, 16(1): 166-169, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem Cell Research, 16(1): 180-183, 2016
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Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem Cell Research, 16(1): 199-201, 2016.

Marthaler A.G., Schmid B., Tubsuwan A., Poulsen U.B., Engelbrecht A.F., Mau-Holzmann U.A., Hyttel P., Nielsen T.T., Nielsen J.E. and Holst B.: Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research, 16(1): 202-205, 2016.

Pajera K, Cs. Nemes, S. Berzsenyi, K. A. Kovács, M. K. Pirity, G. Pajendac, A. Nógrádia, A., Dinnyés. Grafted murine induced pluripotent stem cells prevent death of injured rat motoneurons otherwise destined to die. Experimental Neurology,16 May 2015, 269, pp: 188-201. doi: 10.1016/j.expneurol.2015.03.031

Hall VJ, Lindblad MM, Jakobsen JE, Gunnarsson A, Schmidt M, Rasmussen MA, Volke D, Zuchner T, Hyttel P. Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Dis Model Mech. 2015 Oct 1;8(10):1265-78. doi: 10.1242/dmm.019489.

Tangprasittipap A, Satirapod C, Jittorntrum B, Lertritanan S, Anurathaphan U, Phanthong P, Borwornpinyo S, Kitiyanant N, Hongeng S. Tangprasittipap A., Satirapod C, Jittorntrum B, Lertritanan S, Anurathaphan U, Phanthong P, Borwornpinyo S, Kitiyanant N, Hongeng S. Generation of iPSC line MU011.A-hiPS from homozygous α-thalassemia fetal skin fibroblasts. Stem Cell Res. 2015 Nov;15(3):506-9. doi: 10.1016/j.scr.2015.09.003.

Zhou S., Szczesna K., Ochalek A., Kobolák J., Varga E., Nemes C., Chandrasekaran A., Rasmussen M., Cirera S., Hyttel P., Dinnyés A., Freude K.K., and Avci H.X.: Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells International, Aug. 2015.

Høffding M.K., Hyttel P: Ultrastructural visualization of the Mesenchymal-to-Epithelial Transition during reprogramming of human fibroblasts to induced pluripotent stem cells. Stem CellResearch, Nov. 2014.

Varga E , Juhász G, Bozsó Z, Penke B, Fulop L, and Szegedi V: Abeta (1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors. Neural Plasticity, Sept. 2014.

Rasmussen M.R., Holst B., Tümer Z., Johnsen M.G., Zhou S., Stummann T.C., Hyttel P., and Clausen C.: Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage. Stem Cell Reports, Vol. 3, 404–413, September 9, 2014.

Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A: Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Exp Cell Res. 2014 Apr 1;322(2):335-44.

Nemes C, Varga E, Polgar Z, Klincumhom N, Pirity MK, Dinnyes A.: Generation of Mouse Induced Pluripotent Stem Cells by Protein Transduction. Tissue Eng Part C Methods, 2013 Oct 12. Epub 2013 Oct 10.

Phanthong P, Raveh-Amit H, Li T, Kitiyanant Y, Dinnyes A.: Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells. Biogerontology, 2013 Dec;14(6):591-602. doi: 10.1007/s10522-013-9455-2. Epub 2013 Aug 21.

 

Book Chapters

Rungarunlert, S., Ferreira J.N., Dinnyes A. Novel Bioreactor Platform for Scalable Cardiomyogenic Differentiation from Pluripotent Stem Cell-Derived Embryoid Bodies In: Methods in Molecular Biology, Bioreactors in Stem Cell Biology 5 April 2016, 1502 pp:169-179 doi: 10.1007/7651_2016_341 ISBN 978-1-4939-6478-9 

Pires C, Hall V and Freude KK. Human Induced Pluripotent Stem Cells and their Derivatives for Disease Modeling and Therapeutic Applications in Alzheimer’s Disease. Alzheimer's disease. SMGroup, 2016. p. 1-25. ISBN: 978-1-944685-98-0

 

Conference proceedings 

2013

Dinnyes, A., Varga, E., & Berzsenyi, S. Betegspecifikus őssejtek, majd idegsejtek előállítása bőr és vér minták genetikai újraprogramozásával. Magyar Tudományos Parkinson Társaság konferenciája, Budapest, Hungary. 31. May - 1. June 2013. pp:1-3 (oral presentation)

Kitiyanant, N. Lessons Learned/Best Practices: FP7 in "Thailand's Participation in FP7: A Review", organized by National Science and Technology Development Agency, 8 Nov 2013, Bangkok, Thailand (oral presentation)

Dinnyes, A., Berzsenyi, S., Nemes, C., Varga, E., & Kobolak, J. Emberi indukált pluripotens őssejtek az idegrendszeri és más örökletes betegségek kutatásának szolgálatában. Transzlációs klinikai idegtudományok: az omikától a proteomikáig, 6-7. December 2013, Velence, Hungary. (oral presentation)

Dinnyes, A. 2D and 3D neural structures generated from pluripotent stem cells in mouse and human. Paper presented at the Manchester Tissue Regeneration and Stem Cell Network Seminar Series 2013/2014, 8. November 2013, Manchester, UK. (oral presentation)

 2014

Pajer, K., Nemes, Cs., Berzsenyi, S., Nogradi, A., Dinnyes, A. Grafted mouse iPS cells rescue injured rat motoneurons following ventral root avulsion. 1st. Innovation in Science 2014 - Doctoral Student Conference, 2-3 May, 2014, Szeged, Hungary. (abstract)

Kobolak, J. Indukált pluripotens őssejt alapú betegség- modell létrehozása a központi idegrendszert érintő betegségekben. MBK Napok, 2014, 11-12 December 2014.  Gödöllő, Hungary. (oral presentation)

Dinnyes, A., Berzsenyi, S., Varga, E., Nemes, Cs., & Kobolak, J. ESCs and iPSCs to Generate 2D and 3D Neural Structures for Drug Discovery and Toxicity Testing. 9th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies, 30-31. January 2014, Brussels, Belgium. (oral presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Nemes, C., Varga, E., Bock, I., Zhou, S., Kobolak, J. Patient specific induced pluripotent stem cells and their neuronal differentiation. Annual Meeting of the Hungarian Biochemical Society, 24-27. August 2014, Debrecen, Hungary.p:16 (oral presentation)

Chandrasekaran, A., Roesingh, LN., Nemes, Cs., Varga, E., Bock, I., Zhou, S., Kobolak, J. Induced ploripotent stem cells for biomedical applications. Paper presented at the Innovations in Medicine, 10. October 2014, Budapest, Hungary.p:5 (oral presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Ochalek, A., Nemes, Cs., Varga, E., Bock, I., Kobolak, J. Neuronal differentiation from human induced pluripotent stem cells. IDPbyNMR Final meeting, 21-26. September 2014 Grosseto, Italy. (abstract)

Chandrasekaran, A., Neelchen Roesingh, L., Ochalek, A., Nemes, Cs., Varga, E., Bock, I., Dinnyes, A. Neuronal differentiation of patient specific induced pluripotent stem cells. Stem cells in cancer and regenerative medicine EMBO Conference, 9–12 October 2014, Heidelberg, Germany. (poster presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Berzsenyi, S., Kobolak, J., & Dinnyes, A. Small molecule induced neuronal differentiation of hIPS cell lines through NPC derivation. Paper presented at the Fiatal Biotechnológusok Országos Konferenciája (FIBOK 2014), 7 March 2014, Szeged, Hungary. p:46 (poster presentation)

Kaveh Mashayekhi: Invited guest lecture: Presentation title “Genomics and Bioinformatics in Disease Biomarker Discovery”. University of Vet Medic Hannover. 5 November 2014. University of Veterinary Medicine Hannover (TiHo) Bünteweg 2, 30559 Hannover, Germany. (oral presentation)

Kitiyanant, N., Phanthong, P., Promthem, K., Hongeng, S., Kitiyanant, Y. Generation and characterization of non-integrating human induced pluripotent stem cells from trisomy 21 human fetal fibroblasts. Regional Forum Series 2014, "Global controls in stem cells", organized by International Society for Stem Cell Research and Stem Cell Society Singapore, 5-7 November 2014, Singapore. (poster presentation)

Dinnyes, A. Best practice example: BioTalentum Ltd supported by FP6/7 Stem Cell Research Towards Patient Specific Treatments in V4 Workshop. 1. July 2014. Brussels, Belgium. (oral presentation)

Dinnyes, A. Patient specific induced pluripotent stem cells and their neuronal differentiation. Annual Meeting of the Hungarian Biochemical Society. 2014. 25 August, 2014. Debrecen, Hungary .p:16. (oral presentation0

Kitiyanant, N. Development of Induced Pluripotent Stem Cells (IPSCs) and transdifferentiation into neural stem cells for brain aging and Alzheimer's disease in "Development of Research Strategies for Brain, Mind and Behavior Meeting", organized by National Research Council of Thailand and Health Systems Research Institute, 21-23 July 2014, Bangkok, Thailand. (oral presentation)

2015

Szczesna K., Zhou S., Avci H., Kobolak J., Varga E., Schmidt B., Ochalek A., Freude K., Cirea S., Hyttel P., Dinnyes A. Role of BFGF and EGF in neural rosette formation. Paper presented at the Hungarian Molecular Life Sciences 2015.,  27-29, March, 2015, Eger, Hungary. (poster presentation)

Kobolak J, Chandrasekaran A., Ochalek A., Bellak T., Szegedi V., Varga E., Avci H., Zhou S., Szczesna K., Schmidt B., Dinnyes A. Patient specific induced pluripotent stem cells(IPSCS) and their neuronal differentiation in Alzheimer's disease. Hungarian Molecular Life Sciences 2015. 27-29, March, 2015, Hungary. P:108. (oral presentation)

Kobolak, J., Chandrasekaran, A., Ochalek, A., Bellak, T., Szegedi, V., Varga, E., Dinnyes, A. Patient specific induced pluripotent stem cells (iPSCs) and their neuronal differentiation in Alzheimer’s disease. Hungarian Molecular Life Sciences 2015 27-29 March, 2015, Eger, Hungary. (oral presentation)

Dinnyes, A, Chandrasekaran A., Ochalek A., Tamas B., Sz. Viktor, Avci H., V.  Eszter, T. Annamária, K. Eszter, Szczesna K., Schmidt B., Kobolak J. Betegspecifikus őssejtek differenciójának neurális és kardiális irányokba. Hungarian experimental and clinical pharmacological company's experimental pharmacological IX. Symposium. 26-28.March 2015, Hungary. p:41. (oral presentation)

Dinnyes A., Ochalek A., Chandrasekaran A., Bellak T., Szegedi V., Varga E., Zhou S., Teglasi A., Kovacs E., Szczesna K., Schmidt B., Avci H., Hyttel P., Kobolak J. Modelling the developing CNS by 3D engineered neural tissue from human iPSC; Epigenetics and Periconception Environment, Dubrovnik, Croatia. 26-29, April, 2015 p:18. (oral presentation) 

Dinnyes, A. Személyre szabott őssejtek“ − hogyan lehet bőr vagy vérmintából őssejteket, majd ideg- szív- és más sejttípusokat, szöveteket létrehozni emberben és állatokban. A Szent István Egyetem Állatorvos-tudományi Karának Baráti Köre, Szent István Egyetem, Molekuláris Állatbiotechnológiai Laboratórium, Hungary. 9 September, 2015 (oral presentation)

Dinnyes A, Ochalek A, Chandrasekaran A, Bellák T, Szegedi V, Varga E, Zhou S, Teglasi A, Kovacs E, Szczesna K, Schmidt B, Avci H, Hyttel P, Kobolak J. Modelling the early developing central nervous system by 3D engineered neural tissue from human induced pluripotent stem cells. Epigenetics and Periconception Environment, Dubrovnik, Croatia. 26-29 April 2015 (abstract)

Dinnyes, A., Chandrasekaran, A., Ochalek, A., Bellak, T., Szegedi, V., Avci, H., Varga, E., Teglasi, A., Kovacs, E., Szczesna, K., Schmidt, B., Kobolak, J. Betegspecifikus őssejtek differenciációja neurális és kardiális irányokba. A Magyar Kísérletes és Klinikai Farmakológiai Társaság Experimentális Farmakológiai Szekciójának IX. Szimpoziuma, 26-28. March 2015, Velence, Hungary. (oral presentation)

Chandrasekaran, A., Roesingh, LN., Ochalek, A., Nemes, C., Varga, E., Bock, I., Dinnyes, A. Comparison of 2D and 3D neuronal differentiation of patient specific induced pluripotent stem cells. XV. Biannual Conference of the Hungarian Neuroscience Society Hungarian Academy of Sciences, 22-23 January 2015. Budapest, Hungary, p:44 (poster presentation)

Chandrasekaran, A., Neelchen Roesingh, L., Nemes, C., Varga, E., Bock, I., Zhou, S., Kobolak, J. Neuronal differentiation of human patient specific induced pluripotent stem cells. GlowBrain III. Workshop, Visualisation of molecular markers in the brain, 29-31 January 2015, Zagreb, Croatia. (oral presentation)

Bellak, T., Ochalek, A., Chandrasekaran, A., Szegedi, V., Avci, H., Szczesna, K., Varga, E., Nemes, Cs., Nogradi, A., Kobolak, J., Dinnyes, A. Modelling Alzheimer’s Disease with three-dimensional engineered neural tissue. A MAGYAR ANATÓMUS TÁRSASÁG XIX. KONGRESSZUSA, 11-13 June, 2015, Szeged, Hungary p:39. (poster presentation) 

Bellak T, Chandrasekaran A., Ochalek A., Szegedi V., Varga E., Nemes Cs., Zhou S., Avci H., Kobolak J., Dinnyes A.  3D engineered neural tissue from human induced pluripotent stem cells. Hungarian Molecular Life Sciences 2015. 27-29, March, 2015, Hungary. p:11, (abstract)

Bellak, T., Chandrasekaran, A., Ochalek, A., Szegedi, V., Varga, E., Nemes, C., Dinnyes, A. 3D engineered neural tissue from human induced pluripotent stem cells. Hungarian Molecular Life Sciences 2015, 27-29 March 2015 Eger, Hungary pp:252-253. (abstract)

Bellak, T., Chandrasekaran, A., Ochalek, A., Szegedi, V., Zhou, S., Avci, H., Dinnyes, A. 3D engineered neural tissue from human induced pluripotent stem cells. XV. Biannual Conference of the Hungarian Neuroscience Society, 22-23 January 2015, p: 11, Budapest, Hungary. (abstract)

2016

Francz B., Schmidt B., Ochalek A., Chandrasekaran A., Avci H., Varga E., Kovács E., Kobolak J., Dinnyes A. Induced Pluripotent Stem cell-based in vitro neurotoxicology models. Paper presented at the HunDoc 2016, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, 20 January 2016, Budapest, Hungary. (poster presentation) 

Ochalek A., Bellak T., Chandrasekaran A., Szegedi V., Schmidt B., Bock I., Varga E., Nemes Cs., Zhou S., Hyttel P., Kobolak J., Dinnyes A., Avci H. ENGINEERING HIGH AND LOW COMPLEX 3D NEURAL TISSUE FROM HUMAN INDUCED PLURIPOTENT STEM CELLS. Stem Cell Models of Neural Regeneration and Disease (ISCCS meeting), 1-3 february, 2016, Dresden, Germany. (poster presentation) 

Benjamin Schmid. Genome editing in iPS cells using the CRISPRs/Cas9 system for disease modeling. Tom Wahlig Symposium, 19. 03. 2016, Düsseldorf, Germany. (oral presentation)

Bjørn Holst. Catalyzing Company Development by Exploiting Stem Cell Research Services and Technologies Developed Through Public Private Partnerships – A Danish Perspective, ISRASTEM, 5-6 April 2016, Tel Aviv, Israel (oral presentation)

Benjamin Schmid. Progress on Apoɛ editing. EBiSC General Assembly Meeting No. 3, 7-8 April 2016, Berlin, Germany (oral presentation)

Benjamin Schmid. Modelling Neurodegenerative Diseases Using iPS Cells. EBiSC course 24. 05. 2016, Edinburgh, Scotland.  (oral presentation)

Benjamin Schmid. CRISPRs Technology. Summer Course at KU, 03. 06. 2016, Denmark. (oral presentation)

Benjamin Schmid. Modelling Neurodegenerative Diseases Using iPS Cells. EBiSC course 23. 11. 2016, Edinburgh, Scotland. (oral presentation)

Yu Zhang, Benjamin Schmid, Nanett K. Nikolaisen, Mikkel A. Rasmussen, Troels T. Nielsen, Kirstine Callø, Tina C. Stummann, Hjalte M. Larsen, Blanca Irene Aldana Garcia, Lasse K. Bak, Helle S. Waagepetersen, Jørgen E. Nielsen, Bjørn Holst, Christian Clausen, Poul Hyttel, Kristine K. Freude. Disease modeling of FTD with patient iPSC derived neurons and their isogenic controls. Stem Cell Models of Neural Regeneration and Disease, 1-3 februar, 2016, Dresden, Germany. (abstract)

Pires, C., Turnbull, H., Tubsuwan, A., Freude, K., Nielsen, J., Holst, B., Hyttel, P., Hall, V.J. Pertibation of nucleolar activity in neural progenitors and neurons derived from Alzheimer’s disease patients carrying PSEN1 mutations. Stem Cell Models of Neural Regeneration and Disease, 1-3 februar, 2016, Dresden, Germany. (abstract)

B Schmid, B Holst, A Tubsuwan, MA Rasmussen, TT Nielsen, K Freude, A Marthaler, Y Zhang, P Hyttel, U Bekker-Poulsen, JE Nielsen, and C Clausen. Modelling neurodegenerative diseases based on isogenic gene-corrected iPS cells. Stem Cell Models of Neural Regeneration and Disease, 1-3 februar, 2016, Dresden, Germany. (abstract)

Bjørn Holst, Benjamin Schmid, Mikkel Aabech Rasmussen, Christian Clausen and Lars Hagsholm Pedersen. Reprogramming of Human Somatic Cells into Pluripotent Stem Cells (iPSC) and Gene-editing to build disease specific in vitro models. ISRASTEM, 5-6 April 2016, Tel Aviv, Israel. (abstract)

Carlota Pires, Anna Poon, Benjamin Schmid, Troels T. Nielsen, Lena E. Hjermind, Jørgen Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst, Kristine Freude. Role of PSEN1 in neuronal differentiation and Alzheimer’s disease – modeling human neurodegeneration in a dish. CRISPR genome editing: From high-throughput screening to disease models. Panum, Copenhagen, 21-22 may 2016. (abstract) 

Blanca I. Aldana, Yu Zhang, Lasse K. Bak, Jørgen Nielsen, Bjørn Holst, Poul Hyttel, Kristine K. Freude, Helle Waagepetersen. Neurons derived from human induced pluripotent stem cells as tools for characterizing metabolic pathways in the human brain. 12th International Conference on Brain Energy Metabolism, 25-28 Maj 2016, Hong Kong. (abstract)

Carlota Pires, Anna Poon, Benjamin Schmid, Troels T. Nielsen, Lena E. Hjermind, Jørgen Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst and Kristine Freude. Role of PSEN1 in neuronal differentiation and Alzheimer’s disease – modeling human neurodegenerative diseases in a dish. 10th FENS Forum for Neuroscience, 2-6 July, 2016, Copenhagen, Denmark. (abstract)

B. Schmid, B. Holst, N. Nimsanor, M.A. Rasmussen, U. Bekker-Poulsen, I. Jørring, T. C. Stummann and C. Clausen. Gene-editing technologies allow for the generation of precisely inserted gene cassettes with adjustable expression. DASCS 2016, 10. – 11. November 2016, Rungsted, Denmark. (abstract)

2017

Dinnyes, A. Kobolak, J. Idegrendszeri betegség és toxicitási modellek fejlesztése pluripotens őssejtek segítségével. Bio-Science Kft. Tudományos Napja, 03.May 2017, Budapest, Hunagry- Larus Rendezvényközpont. (oral presentation)

Chandrasekaran A., Avci H., Ochalek A., Molnar K., Laszlo L., Bellak T., Pesti K., Mike A., Kobolak J., Dinnyes A. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells (NPCS) from human iPSCs. A Magyar Kísérletes és Klinikai Farmakológiai Társaság Gyógyszerinnovációs Kongresszusa 07.-09.May 2017, Velence, Hungary (poster presentation). 

Dinnyes A. Neuronal differentiation of human pluripotent stem cells lines. Development of human immortalized and induced pluripotent stem cells for in vitro disease modelling and toxicity testing, EUTOXRISK, Sept 10-13 2017, Bratislava, Slovakia (oral presentation)

Abinaya Chandrasekaran, Hasan Avci, Anna Ochalek, Kinga Molnár, Lajos Laszlo, Tamas Bellak, Krisztina Pesti, Arpad Mike, Julianna Kobolak and Andras Dinnyes. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells (NPCS) from human iPSCs. Hungarian Molecular Life Sciences 2017, March 31-Apr 2, 2017, Hotel Eger & Park, Hungary (poster presentation)

Dinnyes, A. Genetic reprogramming in cloning and stem cells: what we can learn for Assisted Reproduction? Sichuan University, Chengdu Sichuan University, 22 March 2017. Chengdu, China(oral presentation)

Dinnyes A., Chandrasekaran A., Avci H., Ochalek A., Molnar K., Laszlo L., Bellak T., Pesti K., Mike A., and Kobolak J. Comparison of 2D and 3D human iPSC neural induction methods for the generation of neural progenitor cells (NPCs). Poster at Stem Cells: The Next Generation, an ISSCR International Symposium, 10-12 November, 2017; Guangzhou, China; Poster Number: 018 (poster presentation)

 

Outreach activity

Dinnyes, A. Kötetlen beszélgetés Dinnyés Andrással, a Biotalentum Kft igazgatójával XVII. Országos Diákkonferencia. 16 July 2013. Káptalanfüred, Hungary. (invited talk)

Kaveh Mashayekhi: Computational and Systems Biology, way to the target, Research Institute of Biological Psychiatry, Sct. Hans Hospital, 9 May 2014, Roskilde, Denmark (invited talk)

Kristine Freude, Stem cell models of neurodegenerative diseases. DIS, 3 September 2014, Copenhagen, Denmark.

Kitiyanant N. International Research Grant Success Stories: Marie Sklowdowska-Curie Actions (MSCA) in "International Grant Proposal Writing Workshop", organized by Khon Kaen University, 4 July 2017, Khon Kaew, Thailand. (invited talk)